Non-Hodgkin's Lymphoma - Causes, Diagnosis, Symptoms and Treatment
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| Lymphoma can be interpreted as a malignant proliferation of cells derived from the lymphatic system of the body. Lymphomas belong to a certain group of diseases called hematological tumors. Lymphomas are broadly classified into Hodgkin lymphoma and non-Hodgkin's lymphoma (NHL). Non-Hodgkin's lymphoma is described as an uncontrolled proliferation of cancer cells originally found in the bodies of the lymphatic system, including the thymus, lymph nodes, spleen and tonsils. There are several classifications of the NHL, depending on the growth of cancer cells, their origin and size. Depending on the growth, NHL can be divided into high-grade, intermediate grade and low-grade lymphoma. With regard to the origin of the lymphoma, NHL is divided in T-cell lymphoma and B-cell lymphoma. NHL could also be classified as anaplastic large cell lymphoma, small cell lymphoma cell lymphoma and mixed depending on the size of the cell. Another classification is lengthy and follicular NHL type that is based on the spread of the disease. Non-Hodgkin's lymphoma is primarily caused in immuno-compromised individuals infected with micro-organisms such as HIV / AIDS, EBV, Helicobacter pylori, HTLV-1 and Hepatitis C. Age is another prominent factor. NHL is mainly observed in persons older than 60. Some common symptoms observed during the NHL include fever, swollen lymph nodes, but painless, unusual weight loss, excessive sweating, tiredness, uncontrolled cough and respiratory problems. The diagnosis of the disease is made through physical examination of the lymph nodes, blood cells. The stage of the disease was identified through X-rays, CT scans, MRI scan and biopsy. Some of the most common therapeutic approaches for treatment of NHL including chemotherapy, radiation, hematopoietic stem cell transplant or bone marrow transplantation and immune therapy using Rituximab. Chemotherapy used to treat NHL is known as CHOP, a combinatorial approach using drugs such as Cytoxan, Hydroxyrubicin (adriamycin), Oncovin (Vincristine) and Prednisone / prednisolone. |
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