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Chemotherapy Toxicity

Chemotherapy is very effective and uniform treatment of cancer. Most chemotherapy drugs that act on cells by their respective cell cycle including the normal cells of the hair follicles, bone marrow, gastro-intestinal-lining, ovaries, testicles and cancer cells. It helps to determine the side effects of chemotherapy occurred, such as hair loss, diarrhea, mouth ulcers and low blood counts.

The majority of patients receiving chemotherapy toxicity, because it is highly protein bound drugs.
Chemotherapy drugs can affect normal cells or their processes, including the synthesis of DNA and RNA, cell division and many other chemical reactions in the cell. There are some additional medication to alleviate these effects without prejudice to its benefits. You can move in the direction of the acupuncture, nutrition, massage therapy and Reiki.

Patients with chemotherapy of highly protein-bound drugs such as celecoxib, amlodipine and omeprazole combination with chemotherapy medicines may experience side effects such as low haematological count of white blood cells. Patients may also suffer nonhematologic unpleasant effects of chemotherapy, such as diarrhea and fatigue by taking drugs that the cytochrome P450 enzyme, as ketoconazable and amiodarone.

Other factors can affect the chemo-toxicity, including a higher body mass index, tumor stage, lower and higher average serum albumin aminotransferase aspire before the start of chemotherapy. Adjuvant chemotherapy and radiation an excellent advantage with breast cancer. But both can damage normal tissue in the road and affect the quality of life. This effect on normal cells causes attributable to the apoptosis of normal cells.

Ectopic expression of more than anti-apoptotic BCL-2 molecule can absorb the chemotherapy and radiation-induced apoptosis of normal cells and helps to reduce the toxicity of chemotherapy and radiotherapy.

Chemotherapy drugs can also lead to skin toxicity. There is a skin rash such as alopecia, there is hair, acral erythema, remembers reactions, skin necrosis, photosensitivity, acneiform reutions and nail changes, neutrophilic eccrine Hidradenitis, mucositis, hyper pigmentation, sclerotic dermal reactions, vascular damage, xerosis and other reactions.

Acral syndrome is also known as palmoplantar erythrodysesthesia or hand-foot syndrome. It is remarkable with the redness of the skin in the palm of the hand and soles. This may come first by feeling in the skin and severe pain that may affect on the daily activities.

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