Cancer and Healthy

Although there are no precise data for the concordance rates of leukemia in infant twins, incidentally seems to be exceptionally high, perhaps approaching one hundred percent that is, if one twin has, unfortunately, then the other. If correct, suggests that MLL fusion gene in the uterus has a dramatic impact, which later leukemia. But for children aged two to six years with acute lymphoblastic leukemia, the correlation is significantly lower at around five percent. This is still a hundred times more risk of leukemia for the twin brother of a patient with acute lymphoblastic leukemia, but also indicates that there is a need for additional post-natal event for which there is a one in twenty chance, or conflict ninety-five percent. This suggests at least a "two-hit" model for the natural course of the child with leukemia.

If this model of leukemia development is correct, then for every child diagnosed with acute lymphoblastic leukemia, there must be at least twenty healthy children who have a chromosomal translocation, a functional fusion gene leukemia, and a disguised clone preleukaemic generated in the womb. This possibility has been examined independently selected by screening samples from newborn umbilical cord blood for fusion genes. Approximately six hundred samples were screened, and about one percent on a TELAML1 fusion gene leukemia. This percentage represents a hundred times the speed or the cumulative risk of acute lymphoblastic leukemia, indicating that the frequency of the conversion of the preleukaemic clone to overt disease is low. The real bottleneck in the development of acute lymphoblastic leukemia seems therefore a strict requirement for half 'hit' after birth-that is, exposure and additional molecular or chromosomal abnormalities.

An important issue is what risks or events may precipitate the chromosome breaks whose improper repair initiates or promotes children with leukemia. Given the biological diversity of leukemia, it is highly unlikely that there is a single cause. Even for a biological subtype of the disease, there is probably not a cause as such, but a causal mechanism. As with other forms of cancer, this is likely to lead to interaction of exposure, endogenous or exogenous, with inherent genetic susceptibility, and the coincidence. Epidemiological evidence suggests that ionizing radiation, certain chemicals such as benzene, viruses and bacteria may play a role in the development of certain subtypes of leukemia and lymphoma in adults and children.
Or one of these positions have an important role in childhood leukemia is uncertain, but large-scale molecular epidemiological case-control study in Britain and the United States may provide answers. The United Kingdom children's cancer study (UKCCS) seeks to address various hypotheses about the different positions, in combination with a definition of biological and genetic subtypes of disease studies. The parallel and a U.S. study have already ruled out electromagnetic fields as an important factor in the etiology of leukemia.

After the stem cells from umbilical cord blood at birth and stored in a bank or cord blood stem cell bank is a way to prevent your child's future diseases.

It can be very useful because it contains hematopoietic stem cells, progenitor cells. The stem cells in cord blood are used to treat blood and immune system-related hereditary diseases, cancer and blood disorders such as diabetes or leukemia.